A.A.Tillo (1846-1918), the Vice-Governor, was elected the Chairman. He was the person to offer great material support to the board: in 1911, according to his last will, his house was presented to the Board. Up to 1929 the house used to host the SSAB museum, the archives, the library and P.A.Stolypin museum.

In 1889, the museum collection comprised 144 items. That was the reason for S.S. Krasnodubrovskij to compile the first «Systematic catalogue of the SSAB historical museum (1886-1888).

The natural and the historical collections make the important components of the present museum funds. Those were originated in 1895, with the start of the Saratov society for naturalists. The society united both, specialists in natural sciences and enthusiastic admirers of flora and fauna, people involved in state and social activities. P.P. Podyapolskij, a nobleman, a well-known doctor, a member of 14 scientific societies, has left a most important trace in that sphere. Plenty of people used to offer donations.

In November 1921, the city museums were joined together to make the State Regional Museum.

In 1928, collections from naturalist museum were handed to the Regional museum to make the basis for the department of natural history. A.D. Fursaev (1900-1961), a biologist and a future professor of the Saratov State University, played a great role in its foundation.

In 1930, the Museum was transferred to one of the historical monuments: to the former Ustinovs’ family mansion.

Nowadays, the Museum is known as a major center of scientific research in the spheres of local nature, history and culture. Its collections expand permanently, making at present more than 400 000 units.